MindCare
Condition guide

Depression isn't sadness. It's a flattening of everything.

Depression is a neurobiological condition that changes how you think, feel, sleep, eat, and move. It's not a sign of weakness — and pushing through it usually makes it worse. A modern psychiatric evaluation can sort out what kind of depression you have and which treatment is most likely to work for you.

DSM-5-TR

The forms of depression we treat

MDD

Major Depressive Disorder

Episodes of low mood or loss of interest lasting two weeks or more, with cognitive, physical, and motivational changes.

  • Loss of pleasure in usual activities
  • Sleep and appetite changes
  • Difficulty concentrating
  • Hopelessness or guilt
PDD

Persistent Depressive Disorder

A lower-intensity but chronic depression (2+ years) that often feels like "this is just who I am."

  • Chronic low energy
  • Self-criticism as a default
  • Reduced enjoyment over years
  • Functioning, but barely
TRD

Treatment-Resistant Depression

MDD that hasn't responded to at least two adequate medication trials. Often needs reassessment of diagnosis and approach.

  • Tried 2+ antidepressants without relief
  • Possible undiagnosed bipolar spectrum
  • Comorbid ADHD, trauma, or anxiety
  • Candidate for augmentation strategies
What it actually feels like

Common symptoms in adults

Mood & motivation

  • Persistent low mood, emptiness, or irritability
  • Loss of interest (anhedonia)
  • Hopelessness about the future
  • Loss of drive even for things that matter

Cognitive

  • Brain fog, slowed thinking
  • Difficulty making decisions
  • Harsh self-criticism, guilt
  • Concentration and memory complaints

Physical

  • Sleep too much or too little
  • Appetite or weight changes
  • Fatigue that sleep doesn't fix
  • Heaviness, slowed movement, or restlessness

Behavioral

  • Withdrawal from friends and family
  • Falling behind at work or school
  • Letting basics slip (mail, dishes, hygiene)
  • Thoughts of self-harm or not wanting to wake up
Your first visit

What a comprehensive depression evaluation looks like

  1. 01

    Pre-visit intake & screeners

    You'll complete the PHQ-9, GAD-7, MDQ (bipolar screen), AUDIT, and a sleep and trauma history before your visit.

  2. 02

    60-minute clinical interview

    A psychiatric provider explores current symptoms, prior episodes, family history of mood disorders, medical history, medications, substance use, and any history of mania or hypomania.

  3. 03

    Bipolar screen

    We carefully screen for bipolar spectrum disorders, because antidepressants alone can worsen bipolar depression. The MDQ and a structured interview are the standard.

  4. 04

    Medical rule-outs

    Hypothyroidism, anemia, vitamin D and B12 deficiency, sleep apnea, and certain medications can mimic depression. When indicated we recommend labs.

  5. 05

    Suicide-risk assessment

    Every depression evaluation includes a direct, compassionate safety assessment using the C-SSRS framework, with a clear plan if risk is elevated.

  6. 06

    Shared-decision treatment plan

    You leave with a written plan — typically including an SSRI/SNRI or atypical antidepressant, therapy referrals, sleep and movement interventions, and a follow-up cadence.

Evidence-based

The diagnostic tools we use

Primary screener

PHQ-9

Standard 9-item depression severity scale; used at intake and at every follow-up to track response.

Bipolar screen

MDQ (Mood Disorder Questionnaire)

Screens for lifetime hypomanic or manic symptoms — critical before starting an antidepressant.

Anxiety screen

GAD-7

Anxiety is comorbid in over 50% of depression cases and changes the medication choice.

Substance use

AUDIT / DAST

Brief alcohol and drug screens — substances both cause and worsen depression.

Suicide risk

Columbia Suicide Severity Rating Scale (C-SSRS)

The gold-standard safety assessment used in psychiatric care.

Functional impact

WHODAS 2.0

Measures the daily-life impact of depression so progress is visible across treatment.

Differential diagnosis

What we rule out first

Bipolar I / II / cyclothymia
Hypothyroidism
Vitamin D / B12 / iron deficiency
Sleep apnea & chronic insomnia
Perimenopause / postpartum
Chronic pain conditions
ADHD with demoralization
PTSD / cPTSD
Substance use disorders
Medication side effects
Grief vs. depressive episode
Adjustment disorder

After your evaluation

Medication management

Evidence-based use of SSRIs, SNRIs, bupropion, mirtazapine, and augmentation strategies. Careful titration with measurement-based follow-up.

Therapy & behavioral activation

Referrals to CBT, behavioral activation, and IPT — the modalities with the strongest evidence for depression.

Ongoing measurement

PHQ-9 at every visit. We track scores together so improvement is visible and treatment can adapt early.

Ready to feel like yourself again?

Start with our 10-minute assessment. You'll get an instant clinical snapshot and the ability to book a comprehensive evaluation with a psychiatric provider.

This page is educational and does not constitute medical advice. If you're in crisis, call or text 988.